Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1974756..1975532 Replicon chromosome
Accession NZ_LS483311
Organism Staphylococcus aureus strain NCTC6136

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DQL83_RS10180 Protein ID WP_000031108.1
Coordinates 1974756..1974908 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag DQL83_RS10185 Protein ID WP_001251230.1
Coordinates 1974933..1975532 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL83_RS10155 1970671..1971492 + 822 WP_000669376.1 RluA family pseudouridine synthase -
DQL83_RS10160 1971944..1973329 - 1386 WP_000116229.1 class II fumarate hydratase -
DQL83_RS10165 1973525..1973920 - 396 WP_000901023.1 hypothetical protein -
DQL83_RS10180 1974756..1974908 - 153 WP_000031108.1 hypothetical protein Toxin
DQL83_RS10185 1974933..1975532 - 600 WP_001251230.1 hypothetical protein Antitoxin
DQL83_RS10190 1975691..1976161 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQL83_RS10195 1976166..1977293 - 1128 WP_000379988.1 tRNA epoxyqueuosine(34) reductase QueG -
DQL83_RS10200 1977444..1978166 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
DQL83_RS10205 1978159..1979616 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T292291 WP_000031108.1 NZ_LS483311:c1974908-1974756 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22369.51 Da        Isoelectric Point: 4.9728

>AT292291 WP_001251230.1 NZ_LS483311:c1975532-1974933 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKYAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References