Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tsbAT/-
Location 1831106..1831882 Replicon chromosome
Accession NZ_LS483310
Organism Staphylococcus aureus strain NCTC9752

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DQL84_RS09240 Protein ID WP_000031108.1
Coordinates 1831106..1831258 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DQL84_RS09245 Protein ID WP_001251224.1
Coordinates 1831283..1831882 (-) Length 200 a.a.

Genomic Context


DQL84_RS09220DQL84_RS09225DQL84_RS09230DQL84_RS09240DQL84_RS09245DQL84_RS09250DQL84_RS09255DQL84_RS09260DQL84_RS09265
Location: 1827313..1828134 (822 bp)
Type: Others
Protein ID: WP_000669376.1
Location: 1828586..1829971 (1386 bp)
Type: Others
Protein ID: WP_000116229.1
Location: 1830167..1830562 (396 bp)
Type: Others
Protein ID: WP_000901023.1
Location: 1831106..1831258 (153 bp)
Type: Toxin
Protein ID: WP_000031108.1
Location: 1831283..1831882 (600 bp)
Type: Antitoxin
Protein ID: WP_001251224.1
Location: 1832041..1832511 (471 bp)
Type: Others
Protein ID: WP_000181394.1
Location: 1832516..1833643 (1128 bp)
Type: Others
Protein ID: WP_000379980.1
Location: 1833795..1834517 (723 bp)
Type: Others
Protein ID: WP_000590809.1
Location: 1834510..1835967 (1458 bp)
Type: Others
Protein ID: WP_000649907.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DQL84_RS092201827313..1828134+822WP_000669376.1RluA family pseudouridine synthase-
DQL84_RS092251828586..1829971-1386WP_000116229.1class II fumarate hydratase-
DQL84_RS092301830167..1830562-396WP_000901023.1hypothetical protein-
DQL84_RS092401831106..1831258-153WP_000031108.1hypothetical proteinToxin
DQL84_RS092451831283..1831882-600WP_001251224.1glucosamine-6-phosphate isomeraseAntitoxin
DQL84_RS092501832041..1832511-471WP_000181394.1tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL-
DQL84_RS092551832516..1833643-1128WP_000379980.1tRNA epoxyqueuosine(34) reductase QueG-
DQL84_RS092601833795..1834517-723WP_000590809.1amino acid ABC transporter ATP-binding protein-
DQL84_RS092651834510..1835967-1458WP_000649907.1ABC transporter permease subunit-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(124-196)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T292276 WP_000031108.1 NZ_LS483310:c1831258-1831106 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp


Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT292276 WP_001251224.1 NZ_LS483310:c1831882-1831283 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBX5E2E6


Antitoxin

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Source
ID
Structure
AlphaFold DBW8U4V4

References