Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 837505..837982 Replicon chromosome
Accession NC_020568
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAI8T7_RS04035 Protein ID WP_000052076.1
Coordinates 837505..837693 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAI8T7_RS04040 Protein ID WP_001059690.1
Coordinates 837722..837982 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAI8T7_RS04005 833499..834020 + 522 WP_000824485.1 hypothetical protein -
SAI8T7_RS04010 834361..835047 + 687 WP_000141557.1 thermonuclease family protein -
SAI8T7_RS04015 835404..835604 + 201 WP_001059082.1 cold-shock protein -
SAI8T7_RS04020 836096..836314 - 219 WP_000005886.1 hypothetical protein -
SAI8T7_RS04025 836376..836660 - 285 WP_001004399.1 hypothetical protein -
SAI8T7_RS04030 836748..837317 - 570 WP_001106654.1 hypothetical protein -
SAI8T7_RS04035 837505..837693 - 189 WP_000052076.1 hypothetical protein Toxin
SAI8T7_RS04040 837722..837982 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAI8T7_RS04045 838323..838526 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAI8T7_RS04050 838523..838759 - 237 WP_000349581.1 hypothetical protein -
SAI8T7_RS04055 838984..839565 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAI8T7_RS04060 839638..840255 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SAI8T7_RS04065 840410..840904 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAI8T7_RS04070 841303..841725 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAI8T7_RS04075 841873..842589 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T29227 WP_000052076.1 NC_020568:c837693-837505 [Staphylococcus aureus subsp. aureus ST228]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T29227 NC_020568:c837693-837505 [Staphylococcus aureus subsp. aureus ST228]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT29227 WP_001059690.1 NC_020568:c837982-837722 [Staphylococcus aureus subsp. aureus ST228]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT29227 NC_020568:c837982-837722 [Staphylococcus aureus subsp. aureus ST228]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References