Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2239877..2240406 Replicon chromosome
Accession NZ_LS483309
Organism Staphylococcus aureus strain NCTC9944

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQL96_RS11800 Protein ID WP_000621175.1
Coordinates 2239877..2240239 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DQL96_RS11805 Protein ID WP_000948331.1
Coordinates 2240236..2240406 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL96_RS11775 2236856..2237626 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
DQL96_RS11780 2237601..2238080 - 480 WP_001190829.1 anti-sigma B factor RsbW -
DQL96_RS11785 2238082..2238408 - 327 WP_001052491.1 anti-sigma factor antagonist -
DQL96_RS11790 2238527..2239528 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DQL96_RS11800 2239877..2240239 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL96_RS11805 2240236..2240406 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DQL96_RS11810 2240491..2241639 - 1149 WP_001281145.1 alanine racemase -
DQL96_RS11815 2241705..2242064 - 360 WP_000581200.1 holo-ACP synthase -
DQL96_RS11820 2242068..2242559 - 492 WP_001205910.1 PH domain-containing protein -
DQL96_RS11825 2242546..2244129 - 1584 WP_001294626.1 PH domain-containing protein -
DQL96_RS11830 2244122..2244601 - 480 WP_001287088.1 hypothetical protein -
DQL96_RS11835 2244809..2245369 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T292266 WP_000621175.1 NZ_LS483309:c2240239-2239877 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT292266 WP_000948331.1 NZ_LS483309:c2240406-2240236 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References