Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2005390..2006178 Replicon chromosome
Accession NZ_LS483309
Organism Staphylococcus aureus strain NCTC9944

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag DQL96_RS10235 Protein ID WP_000525015.1
Coordinates 2005717..2006178 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag DQL96_RS10230 Protein ID WP_000333632.1
Coordinates 2005390..2005704 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL96_RS10170 2000657..2000917 - 261 WP_000291075.1 DUF1108 family protein -
DQL96_RS10175 2001011..2001331 - 321 WP_000219666.1 hypothetical protein -
DQL96_RS10180 2001332..2001499 - 168 WP_111689341.1 DUF1270 domain-containing protein -
DQL96_RS10185 2001512..2001721 - 210 WP_000455728.1 hypothetical protein -
DQL96_RS10190 2001831..2002016 - 186 Protein_1915 phage repressor protein -
DQL96_RS10195 2002073..2002675 + 603 WP_033863222.1 hypothetical protein -
DQL96_RS10200 2002688..2002828 - 141 WP_111689342.1 hypothetical protein -
DQL96_RS10205 2002812..2003594 - 783 WP_111689343.1 phage antirepressor KilAC domain-containing protein -
DQL96_RS10210 2003596..2003781 - 186 WP_000933365.1 helix-turn-helix transcriptional regulator -
DQL96_RS10215 2004227..2004709 + 483 WP_000394410.1 hypothetical protein -
DQL96_RS10220 2004810..2004989 - 180 WP_000438352.1 hypothetical protein -
DQL96_RS10225 2005008..2005238 - 231 WP_103263741.1 helix-turn-helix domain-containing protein -
DQL96_RS10230 2005390..2005704 + 315 WP_000333632.1 helix-turn-helix domain-containing protein Antitoxin
DQL96_RS10235 2005717..2006178 + 462 WP_000525015.1 hypothetical protein Toxin
DQL96_RS10240 2006196..2006699 + 504 WP_000825944.1 hypothetical protein -
DQL96_RS10245 2006946..2007995 + 1050 WP_000146088.1 site-specific integrase -
DQL96_RS10290 2009271..2009825 - 555 WP_000132890.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1924308..2009825 85517


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18019.38 Da        Isoelectric Point: 4.9167

>T292261 WP_000525015.1 NZ_LS483309:2005717-2006178 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILKAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12091.58 Da        Isoelectric Point: 6.4736

>AT292261 WP_000333632.1 NZ_LS483309:2005390-2005704 [Staphylococcus aureus]
MCFSKRMKQSRERQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References