292252

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2107426..2107940 Replicon chromosome
Accession NZ_LS483308
Organism Staphylococcus aureus strain NCTC13137

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DQL85_RS10880 Protein ID WP_000581792.1
Coordinates 2107426..2107635 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DQL85_RS10885 Protein ID WP_000138932.1
Coordinates 2107647..2107940 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL85_RS10860 2102934..2104292 - 1359 WP_006190765.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DQL85_RS10865 2104307..2105377 - 1071 WP_111743886.1 D-alanine--D-alanine ligase -
DQL85_RS10870 2105695..2106897 + 1203 WP_001109939.1 rod shape-determining protein RodA -
DQL85_RS10875 2107161..2107298 - 138 WP_000828354.1 hypothetical protein -
DQL85_RS10880 2107426..2107635 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DQL85_RS10885 2107647..2107940 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQL85_RS10890 2108106..2109590 + 1485 WP_006190769.1 cardiolipin synthase -
DQL85_RS10895 2109618..2110265 + 648 WP_001187630.1 HD domain-containing protein -
DQL85_RS10910 2110879..2111751 - 873 WP_000725802.1 membrane protein insertase YidC -
DQL85_RS10915 2111837..2112478 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T292252 WP_000581792.1 NZ_LS483308:c2107635-2107426 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT292252 WP_000138932.1 NZ_LS483308:c2107940-2107647 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References