Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 870407..870946 Replicon chromosome
Accession NZ_LS483305
Organism Mammaliicoccus sciuri strain NCTC12103

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag DQL71_RS04125 Protein ID WP_048540867.1
Coordinates 870575..870946 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DQL71_RS04120 Protein ID WP_048540868.1
Coordinates 870407..870574 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL71_RS04095 866289..866768 + 480 WP_048540877.1 PH domain-containing protein -
DQL71_RS04100 866758..868278 + 1521 WP_048540875.1 PH domain-containing protein -
DQL71_RS04105 868268..868732 + 465 WP_048540873.1 PH domain-containing protein -
DQL71_RS04110 868764..869126 + 363 WP_048540871.1 holo-ACP synthase -
DQL71_RS04115 869174..870322 + 1149 WP_048540869.1 alanine racemase -
DQL71_RS04120 870407..870574 + 168 WP_048540868.1 hypothetical protein Antitoxin
DQL71_RS04125 870575..870946 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL71_RS04130 871043..872047 + 1005 WP_048540866.1 PP2C family protein-serine/threonine phosphatase -
DQL71_RS04135 872152..872475 + 324 WP_025904513.1 anti-sigma factor antagonist -
DQL71_RS04140 872480..872956 + 477 WP_025904514.1 anti-sigma B factor RsbW -
DQL71_RS04145 872931..873701 + 771 WP_037589755.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T292241 WP_048540867.1 NZ_LS483305:870575-870946 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6120.58 Da        Isoelectric Point: 4.0121

>AT292241 WP_048540868.1 NZ_LS483305:870407-870574 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYSECEACDSNESHLASQQGE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure

References