Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 765161..765759 Replicon chromosome
Accession NZ_LS483303
Organism Escherichia coli strain NCTC9967

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DQM88_RS03995 Protein ID WP_053270478.1
Coordinates 765382..765759 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID L4J1C0
Locus tag DQM88_RS03990 Protein ID WP_001603498.1
Coordinates 765161..765382 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM88_RS03970 760167..760715 + 549 WP_076486551.1 fimbrial protein YehD -
DQM88_RS03975 760771..761451 + 681 WP_053270475.1 fimbrial assembly chaperone -
DQM88_RS03980 761469..763955 + 2487 WP_111738583.1 fimbria/pilus outer membrane usher protein -
DQM88_RS03985 763966..764976 + 1011 WP_089615833.1 fimbrial protein -
DQM88_RS03990 765161..765382 + 222 WP_001603498.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQM88_RS03995 765382..765759 + 378 WP_053270478.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
DQM88_RS04005 765869..766084 - 216 Protein_723 transposase -
DQM88_RS04015 766270..767532 - 1263 WP_089634553.1 integrase arm-type DNA-binding domain-containing protein -
DQM88_RS04025 767911..768618 - 708 WP_000234514.1 DUF554 domain-containing protein -
DQM88_RS24130 768771..768854 + 84 WP_211180506.1 protein YqgH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 754708..771151 16443
- flank IS/Tn - - 765803..766084 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13419.20 Da        Isoelectric Point: 6.7260

>T292225 WP_053270478.1 NZ_LS483303:765382-765759 [Escherichia coli]
MRHISPEELIAIHDANISRYGGLPGMSDSGRAEAIIGRVQARVAYEEITGLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVYDSPELAELTVGAATGEVSVSTVVATLRRLYGTA

Download         Length: 378 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8190.24 Da        Isoelectric Point: 6.3159

>AT292225 WP_001603498.1 NZ_LS483303:765161-765382 [Escherichia coli]
MQSINFRTARSNLTEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDTTNKKLVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4J1C0

References