292221

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2099023..2099537 Replicon chromosome
Accession NZ_LS483302
Organism Staphylococcus aureus strain NCTC8726

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag DQL80_RS10720 Protein ID WP_000581795.1
Coordinates 2099023..2099232 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag DQL80_RS10725 Protein ID WP_000138934.1
Coordinates 2099244..2099537 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL80_RS10700 2094531..2095889 - 1359 WP_111680492.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DQL80_RS10705 2095904..2096974 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
DQL80_RS10710 2097292..2098494 + 1203 WP_001109939.1 rod shape-determining protein RodA -
DQL80_RS10715 2098758..2098895 - 138 WP_000828354.1 hypothetical protein -
DQL80_RS10720 2099023..2099232 - 210 WP_000581795.1 heavy-metal-associated domain-containing protein Toxin
DQL80_RS10725 2099244..2099537 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQL80_RS10730 2099703..2101187 + 1485 WP_000571561.1 cardiolipin synthase -
DQL80_RS10735 2101215..2101862 + 648 WP_001187624.1 HD domain-containing protein -
DQL80_RS10745 2102509..2103381 - 873 WP_000725802.1 membrane protein insertase YidC -
DQL80_RS10750 2103467..2104108 - 642 WP_000483159.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T292221 WP_000581795.1 NZ_LS483302:c2099232-2099023 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT292221 WP_000138934.1 NZ_LS483302:c2099537-2099244 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References