292220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2079288..2079817 Replicon chromosome
Accession NZ_LS483302
Organism Staphylococcus aureus strain NCTC8726

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQL80_RS10630 Protein ID WP_000621175.1
Coordinates 2079288..2079650 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DQL80_RS10635 Protein ID WP_000948331.1
Coordinates 2079647..2079817 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL80_RS10605 2076267..2077037 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DQL80_RS10610 2077012..2077491 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DQL80_RS10615 2077493..2077819 - 327 WP_001052491.1 anti-sigma factor antagonist -
DQL80_RS10620 2077938..2078939 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DQL80_RS10630 2079288..2079650 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL80_RS10635 2079647..2079817 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DQL80_RS10640 2079902..2081050 - 1149 WP_111680484.1 alanine racemase -
DQL80_RS10645 2081116..2081475 - 360 WP_000581197.1 holo-ACP synthase -
DQL80_RS10650 2081479..2081970 - 492 WP_001205907.1 PH domain-containing protein -
DQL80_RS10655 2081957..2083540 - 1584 WP_111680485.1 PH domain-containing protein -
DQL80_RS10660 2083533..2084012 - 480 WP_111680486.1 hypothetical protein -
DQL80_RS10665 2084216..2084776 - 561 WP_111680487.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T292220 WP_000621175.1 NZ_LS483302:c2079650-2079288 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT292220 WP_000948331.1 NZ_LS483302:c2079817-2079647 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References