Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1885267..1886043 Replicon chromosome
Accession NZ_LS483302
Organism Staphylococcus aureus strain NCTC8726

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DQL80_RS09395 Protein ID WP_000031108.1
Coordinates 1885267..1885419 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DQL80_RS09400 Protein ID WP_001251224.1
Coordinates 1885444..1886043 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL80_RS09375 1881184..1882005 + 822 WP_111680437.1 RluA family pseudouridine synthase -
DQL80_RS09380 1882461..1883846 - 1386 WP_111680438.1 class II fumarate hydratase -
DQL80_RS09385 1884042..1884437 - 396 WP_000901023.1 hypothetical protein -
DQL80_RS09395 1885267..1885419 - 153 WP_000031108.1 hypothetical protein Toxin
DQL80_RS09400 1885444..1886043 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DQL80_RS09405 1886202..1886672 - 471 WP_111680440.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQL80_RS09410 1886677..1887804 - 1128 WP_000379991.1 tRNA epoxyqueuosine(34) reductase QueG -
DQL80_RS09415 1887955..1888677 - 723 WP_172452451.1 ATP-binding cassette domain-containing protein -
DQL80_RS09420 1888670..1890127 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T292218 WP_000031108.1 NZ_LS483302:c1885419-1885267 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT292218 WP_001251224.1 NZ_LS483302:c1886043-1885444 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References