Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2023617..2024393 Replicon chromosome
Accession NZ_LS483301
Organism Staphylococcus aureus strain NCTC13394

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DQL88_RS10450 Protein ID WP_000031108.1
Coordinates 2023617..2023769 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DQL88_RS10455 Protein ID WP_001251224.1
Coordinates 2023794..2024393 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL88_RS10425 2019580..2020401 + 822 WP_000669376.1 RluA family pseudouridine synthase -
DQL88_RS10430 2020864..2022249 - 1386 WP_000116224.1 class II fumarate hydratase -
DQL88_RS10435 2022445..2022840 - 396 WP_000901021.1 hypothetical protein -
DQL88_RS10450 2023617..2023769 - 153 WP_000031108.1 hypothetical protein Toxin
DQL88_RS10455 2023794..2024393 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DQL88_RS10460 2024552..2025022 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQL88_RS10465 2025027..2026154 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
DQL88_RS10470 2026305..2027027 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
DQL88_RS10475 2027020..2028477 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / lukD / hlgA 1951695..2031650 79955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T292203 WP_000031108.1 NZ_LS483301:c2023769-2023617 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT292203 WP_001251224.1 NZ_LS483301:c2024393-2023794 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References