Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2067352..2067866 Replicon chromosome
Accession NZ_LS483300
Organism Staphylococcus aureus strain NCTC7485

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DQL62_RS10640 Protein ID WP_000581792.1
Coordinates 2067352..2067561 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag DQL62_RS10645 Protein ID WP_000138929.1
Coordinates 2067573..2067866 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL62_RS10620 2062860..2064218 - 1359 WP_000611485.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DQL62_RS10625 2064233..2065303 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
DQL62_RS10630 2065621..2066823 + 1203 WP_001109943.1 rod shape-determining protein RodA -
DQL62_RS10635 2067087..2067224 - 138 WP_000828354.1 hypothetical protein -
DQL62_RS10640 2067352..2067561 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DQL62_RS10645 2067573..2067866 - 294 WP_000138929.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQL62_RS10650 2068032..2069516 + 1485 WP_000571547.1 cardiolipin synthase -
DQL62_RS10655 2069544..2070191 + 648 WP_001187616.1 HD domain-containing protein -
DQL62_RS10665 2070855..2071727 - 873 WP_111725130.1 membrane protein insertase YidC -
DQL62_RS10670 2071813..2072454 - 642 WP_000483166.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T292195 WP_000581792.1 NZ_LS483300:c2067561-2067352 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11215.86 Da        Isoelectric Point: 6.2243

>AT292195 WP_000138929.1 NZ_LS483300:c2067866-2067573 [Staphylococcus aureus]
MTEQDNAHHSEQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure

References