Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1874450..1875226 Replicon chromosome
Accession NZ_LS483300
Organism Staphylococcus aureus strain NCTC7485

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag DQL62_RS09505 Protein ID WP_000031105.1
Coordinates 1874450..1874602 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag DQL62_RS09510 Protein ID WP_001251219.1
Coordinates 1874627..1875226 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL62_RS09485 1870716..1871537 + 822 WP_000669372.1 RluA family pseudouridine synthase -
DQL62_RS09490 1871988..1873373 - 1386 WP_045158592.1 class II fumarate hydratase -
DQL62_RS09495 1873569..1873964 - 396 WP_000901023.1 hypothetical protein -
DQL62_RS09505 1874450..1874602 - 153 WP_000031105.1 hypothetical protein Toxin
DQL62_RS09510 1874627..1875226 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
DQL62_RS09515 1875385..1875855 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQL62_RS09520 1875860..1876987 - 1128 WP_000379976.1 tRNA epoxyqueuosine(34) reductase QueG -
DQL62_RS09525 1877138..1877860 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
DQL62_RS09530 1877853..1879310 - 1458 WP_000649895.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5922.25 Da        Isoelectric Point: 3.8849

>T292193 WP_000031105.1 NZ_LS483300:c1874602-1874450 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKDLGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT292193 WP_001251219.1 NZ_LS483300:c1875226-1874627 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References