Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2071202..2071731 Replicon chromosome
Accession NC_020566
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SAI5S5_RS10385 Protein ID WP_000621175.1
Coordinates 2071202..2071564 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag SAI5S5_RS10390 Protein ID WP_000948331.1
Coordinates 2071561..2071731 (-) Length 57 a.a.

Genomic Context


SAI5S5_RS10360SAI5S5_RS10365SAI5S5_RS10370SAI5S5_RS10375SAI5S5_RS10385SAI5S5_RS10390SAI5S5_RS10395SAI5S5_RS10400SAI5S5_RS10405SAI5S5_RS10410SAI5S5_RS10415SAI5S5_RS10420
Location: 2068180..2068950 (771 bp)
Type: Others
Protein ID: WP_001041111.1
Location: 2068925..2069404 (480 bp)
Type: Others
Protein ID: WP_001190829.1
Location: 2069406..2069732 (327 bp)
Type: Others
Protein ID: WP_001052491.1
Location: 2069851..2070852 (1002 bp)
Type: Others
Protein ID: WP_000390829.1
Location: 2071202..2071564 (363 bp)
Type: Toxin
Protein ID: WP_000621175.1
Location: 2071561..2071731 (171 bp)
Type: Antitoxin
Protein ID: WP_000948331.1
Location: 2071816..2072964 (1149 bp)
Type: Others
Protein ID: WP_001281154.1
Location: 2073030..2073389 (360 bp)
Type: Others
Protein ID: WP_000581197.1
Location: 2073393..2073884 (492 bp)
Type: Others
Protein ID: WP_001205912.1
Location: 2073871..2075454 (1584 bp)
Type: Others
Protein ID: WP_001294626.1
Location: 2075447..2075926 (480 bp)
Type: Others
Protein ID: WP_001287087.1
Location: 2076134..2076694 (561 bp)
Type: Others
Protein ID: WP_001092411.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SAI5S5_RS103602068180..2068950-771WP_001041111.1RNA polymerase sigma factor SigB-
SAI5S5_RS103652068925..2069404-480WP_001190829.1anti-sigma B factor RsbW-
SAI5S5_RS103702069406..2069732-327WP_001052491.1anti-sigma factor antagonist-
SAI5S5_RS103752069851..2070852-1002WP_000390829.1PP2C family protein-serine/threonine phosphatase-
SAI5S5_RS103852071202..2071564-363WP_000621175.1type II toxin-antitoxin system PemK/MazF family toxinToxin
SAI5S5_RS103902071561..2071731-171WP_000948331.1type II toxin-antitoxin system antitoxin MazEAntitoxin
SAI5S5_RS103952071816..2072964-1149WP_001281154.1alanine racemase-
SAI5S5_RS104002073030..2073389-360WP_000581197.1holo-ACP synthase-
SAI5S5_RS104052073393..2073884-492WP_001205912.1PH domain-containing protein-
SAI5S5_RS104102073871..2075454-1584WP_001294626.1PH domain-containing protein-
SAI5S5_RS104152075447..2075926-480WP_001287087.1hypothetical protein-
SAI5S5_RS104202076134..2076694-561WP_001092411.1K(+)-transporting ATPase subunit C-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T29219 WP_000621175.1 NC_020566:c2071564-2071202 [Staphylococcus aureus subsp. aureus ST228]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T29219 NC_020566:c2071564-2071202 [Staphylococcus aureus subsp. aureus ST228]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT29219 WP_000948331.1 NC_020566:c2071731-2071561 [Staphylococcus aureus subsp. aureus ST228]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT29219 NC_020566:c2071731-2071561 [Staphylococcus aureus subsp. aureus ST228]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0VRZ1

References