Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 2071202..2071731 | Replicon | chromosome |
Accession | NC_020566 | ||
Organism | Staphylococcus aureus subsp. aureus ST228 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | - |
Locus tag | SAI5S5_RS10385 | Protein ID | WP_000621175.1 |
Coordinates | 2071202..2071564 (-) | Length | 121 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | T1YCG8 |
Locus tag | SAI5S5_RS10390 | Protein ID | WP_000948331.1 |
Coordinates | 2071561..2071731 (-) | Length | 57 a.a. |
Genomic Context
Location: 2068180..2068950 (771 bp)
Type: Others
Protein ID: WP_001041111.1
Type: Others
Protein ID: WP_001041111.1
Location: 2068925..2069404 (480 bp)
Type: Others
Protein ID: WP_001190829.1
Type: Others
Protein ID: WP_001190829.1
Location: 2069406..2069732 (327 bp)
Type: Others
Protein ID: WP_001052491.1
Type: Others
Protein ID: WP_001052491.1
Location: 2069851..2070852 (1002 bp)
Type: Others
Protein ID: WP_000390829.1
Type: Others
Protein ID: WP_000390829.1
Location: 2071202..2071564 (363 bp)
Type: Toxin
Protein ID: WP_000621175.1
Type: Toxin
Protein ID: WP_000621175.1
Location: 2071561..2071731 (171 bp)
Type: Antitoxin
Protein ID: WP_000948331.1
Type: Antitoxin
Protein ID: WP_000948331.1
Location: 2071816..2072964 (1149 bp)
Type: Others
Protein ID: WP_001281154.1
Type: Others
Protein ID: WP_001281154.1
Location: 2073030..2073389 (360 bp)
Type: Others
Protein ID: WP_000581197.1
Type: Others
Protein ID: WP_000581197.1
Location: 2073393..2073884 (492 bp)
Type: Others
Protein ID: WP_001205912.1
Type: Others
Protein ID: WP_001205912.1
Location: 2073871..2075454 (1584 bp)
Type: Others
Protein ID: WP_001294626.1
Type: Others
Protein ID: WP_001294626.1
Location: 2075447..2075926 (480 bp)
Type: Others
Protein ID: WP_001287087.1
Type: Others
Protein ID: WP_001287087.1
Location: 2076134..2076694 (561 bp)
Type: Others
Protein ID: WP_001092411.1
Type: Others
Protein ID: WP_001092411.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SAI5S5_RS10360 | 2068180..2068950 | - | 771 | WP_001041111.1 | RNA polymerase sigma factor SigB | - |
SAI5S5_RS10365 | 2068925..2069404 | - | 480 | WP_001190829.1 | anti-sigma B factor RsbW | - |
SAI5S5_RS10370 | 2069406..2069732 | - | 327 | WP_001052491.1 | anti-sigma factor antagonist | - |
SAI5S5_RS10375 | 2069851..2070852 | - | 1002 | WP_000390829.1 | PP2C family protein-serine/threonine phosphatase | - |
SAI5S5_RS10385 | 2071202..2071564 | - | 363 | WP_000621175.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
SAI5S5_RS10390 | 2071561..2071731 | - | 171 | WP_000948331.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
SAI5S5_RS10395 | 2071816..2072964 | - | 1149 | WP_001281154.1 | alanine racemase | - |
SAI5S5_RS10400 | 2073030..2073389 | - | 360 | WP_000581197.1 | holo-ACP synthase | - |
SAI5S5_RS10405 | 2073393..2073884 | - | 492 | WP_001205912.1 | PH domain-containing protein | - |
SAI5S5_RS10410 | 2073871..2075454 | - | 1584 | WP_001294626.1 | PH domain-containing protein | - |
SAI5S5_RS10415 | 2075447..2075926 | - | 480 | WP_001287087.1 | hypothetical protein | - |
SAI5S5_RS10420 | 2076134..2076694 | - | 561 | WP_001092411.1 | K(+)-transporting ATPase subunit C | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13441.69 Da Isoelectric Point: 10.1654
>T29219 WP_000621175.1 NC_020566:c2071564-2071202 [Staphylococcus aureus subsp. aureus ST228]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
Download Length: 363 bp
>T29219 NC_020566:c2071564-2071202 [Staphylococcus aureus subsp. aureus ST228]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
Antitoxin
Download Length: 57 a.a. Molecular weight: 6251.78 Da Isoelectric Point: 3.8305
>AT29219 WP_000948331.1 NC_020566:c2071731-2071561 [Staphylococcus aureus subsp. aureus ST228]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
Download Length: 171 bp
>AT29219 NC_020566:c2071731-2071561 [Staphylococcus aureus subsp. aureus ST228]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
Structures
Toxin
Loading, please wait
Source | ID | Structure |
---|---|---|
No matching records found |
Antitoxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VRZ1 |