292185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 3686890..3687569 Replicon chromosome
Accession NZ_LS483297
Organism Escherichia coli strain NCTC11023

Toxin (Protein)


Gene name ykfI Uniprot ID S1FHS4
Locus tag DQM98_RS19215 Protein ID WP_000854680.1
Coordinates 3687228..3687569 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID S1EWR7
Locus tag DQM98_RS19210 Protein ID WP_000070396.1
Coordinates 3686890..3687207 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM98_RS19165 3682328..3683149 + 822 WP_001548153.1 DUF945 domain-containing protein -
DQM98_RS19170 3683366..3684067 + 702 WP_021553244.1 WYL domain-containing protein -
DQM98_RS19175 3684108..3684344 + 237 WP_001144029.1 hypothetical protein -
DQM98_RS19180 3684344..3684787 + 444 WP_021553245.1 hypothetical protein -
DQM98_RS19185 3684810..3685277 + 468 WP_001385283.1 hypothetical protein -
DQM98_RS19190 3685354..3685593 + 240 Protein_3508 DUF905 domain-containing protein -
DQM98_RS19195 3685691..3686149 + 459 WP_000211838.1 antirestriction protein -
DQM98_RS19200 3686165..3686641 + 477 WP_000811693.1 RadC family protein -
DQM98_RS19205 3686650..3686871 + 222 WP_000691994.1 DUF987 domain-containing protein -
DQM98_RS19210 3686890..3687207 + 318 WP_000070396.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
DQM98_RS19215 3687228..3687569 + 342 WP_000854680.1 type IV toxin-antitoxin system toxin YkfI Toxin
DQM98_RS19220 3688088..3689161 + 1074 WP_057081038.1 site-specific integrase -
DQM98_RS19225 3689172..3690101 + 930 WP_057081037.1 hypothetical protein -
DQM98_RS19230 3690169..3690396 - 228 WP_001403510.1 hypothetical protein -
DQM98_RS19235 3690466..3691851 - 1386 WP_057081036.1 P-type conjugative transfer protein TrbL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3660750..3724333 63583


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12892.95 Da        Isoelectric Point: 9.6543

>T292185 WP_000854680.1 NZ_LS483297:3687228-3687569 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11982.62 Da        Isoelectric Point: 7.0270

>AT292185 WP_000070396.1 NZ_LS483297:3686890-3687207 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHS4

Antitoxin

Source ID Structure
AlphaFold DB S1EWR7

References