Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3452595..3453213 Replicon chromosome
Accession NZ_LS483297
Organism Escherichia coli strain NCTC11023

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag DQM98_RS17900 Protein ID WP_001291435.1
Coordinates 3452995..3453213 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag DQM98_RS17895 Protein ID WP_000344800.1
Coordinates 3452595..3452969 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM98_RS17885 3447684..3448877 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DQM98_RS17890 3448900..3452049 + 3150 WP_073528120.1 efflux RND transporter permease AcrB -
DQM98_RS17895 3452595..3452969 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
DQM98_RS17900 3452995..3453213 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
DQM98_RS17905 3453385..3453936 + 552 WP_000102564.1 maltose O-acetyltransferase -
DQM98_RS17910 3454052..3454522 + 471 WP_000136192.1 YlaC family protein -
DQM98_RS17915 3454686..3456236 + 1551 WP_073528553.1 cyclic-guanylate-specific phosphodiesterase PdeB -
DQM98_RS17920 3456278..3456631 - 354 WP_000878140.1 DUF1428 domain-containing protein -
DQM98_RS17930 3457010..3457321 + 312 WP_000409911.1 MGMT family protein -
DQM98_RS17935 3457352..3457924 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T292183 WP_001291435.1 NZ_LS483297:3452995-3453213 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT292183 WP_000344800.1 NZ_LS483297:3452595-3452969 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References