Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2464848..2465486 Replicon chromosome
Accession NZ_LS483297
Organism Escherichia coli strain NCTC11023

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag DQM98_RS12670 Protein ID WP_000813794.1
Coordinates 2465310..2465486 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DQM98_RS12665 Protein ID WP_001270286.1
Coordinates 2464848..2465264 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM98_RS12645 2460000..2460941 - 942 WP_001251319.1 ABC transporter permease -
DQM98_RS12650 2460942..2461955 - 1014 WP_000220393.1 ABC transporter ATP-binding protein -
DQM98_RS12655 2461973..2463118 - 1146 WP_000047429.1 ABC transporter substrate-binding protein -
DQM98_RS12660 2463360..2464769 - 1410 WP_000760649.1 PLP-dependent aminotransferase family protein -
DQM98_RS12665 2464848..2465264 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
DQM98_RS12670 2465310..2465486 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
DQM98_RS12675 2465708..2465938 + 231 WP_000494244.1 YncJ family protein -
DQM98_RS12680 2466030..2467991 - 1962 WP_024179169.1 23S rRNA 5-hydroxycytidine C2501 synthase -
DQM98_RS12685 2468064..2468600 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
DQM98_RS12690 2468653..2469882 + 1230 WP_111732518.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2469922..2471070 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T292182 WP_000813794.1 NZ_LS483297:c2465486-2465310 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT292182 WP_001270286.1 NZ_LS483297:c2465264-2464848 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References