292168

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 3690805..3691484 Replicon chromosome
Accession NZ_LS483296
Organism Escherichia coli strain NCTC9966

Toxin (Protein)


Gene name ykfI Uniprot ID S1FHS4
Locus tag DQM96_RS19345 Protein ID WP_000854680.1
Coordinates 3691143..3691484 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID S1EWR7
Locus tag DQM96_RS19340 Protein ID WP_000070396.1
Coordinates 3690805..3691122 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM96_RS19295 3686243..3687064 + 822 WP_000197387.1 DUF945 domain-containing protein -
DQM96_RS19300 3687281..3687982 + 702 WP_111724748.1 WYL domain-containing protein -
DQM96_RS19305 3688023..3688259 + 237 WP_001144031.1 hypothetical protein -
DQM96_RS19310 3688259..3688702 + 444 WP_000649865.1 hypothetical protein -
DQM96_RS19315 3688725..3689192 + 468 WP_001385283.1 hypothetical protein -
DQM96_RS19320 3689269..3689508 + 240 WP_000194654.1 DUF905 domain-containing protein -
DQM96_RS19325 3689606..3690064 + 459 WP_000211838.1 antirestriction protein -
DQM96_RS19330 3690080..3690556 + 477 WP_000811693.1 RadC family protein -
DQM96_RS19335 3690565..3690786 + 222 WP_001568590.1 DUF987 domain-containing protein -
DQM96_RS19340 3690805..3691122 + 318 WP_000070396.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
DQM96_RS19345 3691143..3691484 + 342 WP_000854680.1 type IV toxin-antitoxin system toxin YkfI Toxin
DQM96_RS19350 3692062..3693126 - 1065 Protein_3540 phosphoribosyl transferase -
DQM96_RS19360 3694385..3694552 - 168 Protein_3542 phosphoribosyl transferase -
DQM96_RS19365 3694563..3695543 - 981 WP_001567470.1 DNA-protecting protein DprA -
DQM96_RS19370 3695959..3696231 - 273 WP_001185343.1 ogr/Delta-like zinc finger family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12892.95 Da        Isoelectric Point: 9.6543

>T292168 WP_000854680.1 NZ_LS483296:3691143-3691484 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11982.62 Da        Isoelectric Point: 7.0270

>AT292168 WP_000070396.1 NZ_LS483296:3690805-3691122 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHS4

Antitoxin

Source ID Structure
AlphaFold DB S1EWR7

References