Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1144478..1145145 Replicon chromosome
Accession NZ_LS483296
Organism Escherichia coli strain NCTC9966

Toxin (Protein)


Gene name ypjF Uniprot ID A0A156PNF2
Locus tag DQM96_RS05880 Protein ID WP_001618791.1
Coordinates 1144478..1144807 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A156PNH9
Locus tag DQM96_RS05885 Protein ID WP_001618790.1
Coordinates 1144828..1145145 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM96_RS05875 1139534..1144114 + 4581 WP_111724795.1 adhesin-like autotransporter YpjA/EhaD -
DQM96_RS05880 1144478..1144807 - 330 WP_001618791.1 TA system toxin CbtA family protein Toxin
DQM96_RS05885 1144828..1145145 - 318 WP_001618790.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DQM96_RS05890 1145164..1145385 - 222 WP_044864853.1 DUF987 domain-containing protein -
DQM96_RS05895 1145394..1145870 - 477 WP_000811693.1 RadC family protein -
DQM96_RS05900 1145886..1146344 - 459 WP_000211838.1 antirestriction protein -
DQM96_RS05905 1146442..1146681 - 240 WP_000194654.1 DUF905 domain-containing protein -
DQM96_RS05910 1146758..1147225 - 468 WP_001547765.1 hypothetical protein -
DQM96_RS05915 1147248..1147691 - 444 WP_032199444.1 hypothetical protein -
DQM96_RS05920 1147691..1147927 - 237 WP_001144031.1 hypothetical protein -
DQM96_RS05925 1147968..1148669 - 702 WP_111724571.1 WYL domain-containing protein -
DQM96_RS05930 1148886..1149707 - 822 WP_111724572.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1135533..1176366 40833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12509.43 Da        Isoelectric Point: 7.2767

>T292160 WP_001618791.1 NZ_LS483296:c1144807-1144478 [Escherichia coli]
MNTLPATTQRAAKPCLSPVAVWKMLLTHLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADTVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTDLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11905.54 Da        Isoelectric Point: 7.3234

>AT292160 WP_001618790.1 NZ_LS483296:c1145145-1144828 [Escherichia coli]
MSNITWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDAECRKLDETFPHFIRQMESMLTTGEVSPQHAHCVILYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A156PNF2

Antitoxin

Source ID Structure
AlphaFold DB A0A156PNH9

References