Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1310859..1312458 Replicon chromosome
Accession NZ_LS483259
Organism Bordetella pertussis strain BP6242 isolate Bordetella pertussis

Toxin (Protein)


Gene name hipA Uniprot ID Q7VVM6
Locus tag JMW36_RS06250 Protein ID WP_003816876.1
Coordinates 1311118..1312458 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW36_RS06245 Protein ID WP_019247974.1
Coordinates 1310859..1311116 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW36_RS06230 1306522..1307133 - 612 WP_010931041.1 DUF2239 family protein -
JMW36_RS06235 1307356..1308816 + 1461 WP_003812368.1 IMP dehydrogenase -
JMW36_RS06240 1308913..1310505 + 1593 WP_010931040.1 glutamine-hydrolyzing GMP synthase -
JMW36_RS06245 1310859..1311116 + 258 WP_019247974.1 helix-turn-helix domain-containing protein Antitoxin
JMW36_RS06250 1311118..1312458 + 1341 WP_003816876.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW36_RS06255 1312554..1313243 - 690 WP_010931038.1 TetR/AcrR family transcriptional regulator -
JMW36_RS06260 1313256..1314686 + 1431 WP_019247976.1 MFS transporter -
JMW36_RS06265 1314918..1315996 + 1079 Protein_1232 tellurite resistance/C4-dicarboxylate transporter family protein -
JMW36_RS06270 1316411..1317232 + 822 WP_014905903.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49632.79 Da        Isoelectric Point: 7.4158

>T292151 WP_003816876.1 NZ_LS483259:1311118-1312458 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Download         Length: 1341 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8815.04 Da        Isoelectric Point: 7.1642

>AT292151 WP_019247974.1 NZ_LS483259:1310859-1311116 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7VVM6

Antitoxin

Source ID Structure

References