Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2742052..2743651 Replicon chromosome
Accession NZ_LS483252
Organism Bordetella pertussis strain BP82 isolate Bordetella pertussis

Toxin (Protein)


Gene name hipA Uniprot ID Q7VVM6
Locus tag JMW63_RS13180 Protein ID WP_003816876.1
Coordinates 2742052..2743392 (-) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW63_RS13185 Protein ID WP_019247974.1
Coordinates 2743394..2743651 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW63_RS13160 2737278..2738099 - 822 WP_014905903.1 IclR family transcriptional regulator -
JMW63_RS13165 2738514..2739592 - 1079 Protein_2583 tellurite resistance/C4-dicarboxylate transporter family protein -
JMW63_RS13170 2739824..2741254 - 1431 WP_019247976.1 MFS transporter -
JMW63_RS13175 2741267..2741956 + 690 WP_010931038.1 TetR/AcrR family transcriptional regulator -
JMW63_RS13180 2742052..2743392 - 1341 WP_003816876.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW63_RS13185 2743394..2743651 - 258 WP_019247974.1 helix-turn-helix domain-containing protein Antitoxin
JMW63_RS13190 2744005..2745597 - 1593 WP_010931040.1 glutamine-hydrolyzing GMP synthase -
JMW63_RS13195 2745694..2747154 - 1461 WP_003812368.1 IMP dehydrogenase -
JMW63_RS13200 2747377..2747988 + 612 WP_010931041.1 DUF2239 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49632.79 Da        Isoelectric Point: 7.4158

>T292140 WP_003816876.1 NZ_LS483252:c2743392-2742052 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Download         Length: 1341 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8815.04 Da        Isoelectric Point: 7.1642

>AT292140 WP_019247974.1 NZ_LS483252:c2743651-2743394 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7VVM6

Antitoxin

Source ID Structure

References