Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1148528..1149036 Replicon chromosome
Accession NZ_LS483250
Organism Moritella yayanosii strain DB21MT 5

Toxin (Protein)


Gene name relE Uniprot ID A9DLP5
Locus tag MORIYA_RS05130 Protein ID WP_005503217.1
Coordinates 1148776..1149036 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A330M9Z2
Locus tag MORIYA_RS05125 Protein ID WP_040572210.1
Coordinates 1148528..1148779 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MORIYA_RS05100 1143845..1145326 - 1482 WP_112713257.1 FAD-dependent monooxygenase -
MORIYA_RS05105 1145453..1145575 + 123 Protein_990 IS1595 family transposase -
MORIYA_RS05110 1145574..1145790 - 217 Protein_991 transposase domain-containing protein -
MORIYA_RS05115 1145922..1146368 - 447 WP_162629227.1 polymer-forming cytoskeletal protein -
MORIYA_RS05120 1146331..1147557 - 1227 WP_112713261.1 M23 family metallopeptidase -
MORIYA_RS05125 1148528..1148779 + 252 WP_040572210.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MORIYA_RS05130 1148776..1149036 + 261 WP_005503217.1 Txe/YoeB family addiction module toxin Toxin
MORIYA_RS05135 1149137..1149664 + 528 Protein_996 transposase -
MORIYA_RS05140 1149842..1150114 + 273 WP_112713263.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MORIYA_RS05145 1150095..1150364 + 270 WP_112713265.1 Txe/YoeB family addiction module toxin -
MORIYA_RS05150 1151110..1151766 - 657 WP_112713267.1 LysE family translocator -
MORIYA_RS20735 1151908..1152084 + 177 WP_162629203.1 hypothetical protein -
MORIYA_RS05155 1152081..1153028 + 948 WP_112713269.1 transposase -
MORIYA_RS05160 1153291..1153572 - 282 WP_112713271.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1149317..1149685 368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10380.97 Da        Isoelectric Point: 10.1628

>T292131 WP_005503217.1 NZ_LS483250:1148776-1149036 [Moritella yayanosii]
MKLTFATKAWENYLYWQTTDKKMLKRINTLIKDIQRSPYSGIGKPEPLKHGLAGYWSRRINDEHRIVYKYQDDTILIAQL
RYHYST

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9195.45 Da        Isoelectric Point: 4.2837

>AT292131 WP_040572210.1 NZ_LS483250:1148528-1148779 [Moritella yayanosii]
MDAISYTSARANLASTMAQVCNDHAPIIITRKSEAPVVMMSLEDYQAMEETTYLLRSPANARYLLESIAELEAGKGTERE
LLE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9DLP5

Antitoxin

Source ID Structure
AlphaFold DB A0A330M9Z2

References