Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2383548..2384173 Replicon chromosome
Accession NZ_LS399318
Organism Klebsiella pneumoniae isolate CNR48

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CNR480_RS11440 Protein ID WP_040182550.1
Coordinates 2383548..2383931 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag CNR480_RS11445 Protein ID WP_004150355.1
Coordinates 2383931..2384173 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNR480_RS11425 2380914..2381816 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
CNR480_RS11430 2381813..2382448 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
CNR480_RS11435 2382445..2383374 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
CNR480_RS11440 2383548..2383931 - 384 WP_040182550.1 type II toxin-antitoxin system VapC family toxin Toxin
CNR480_RS11445 2383931..2384173 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
CNR480_RS11450 2384378..2385295 + 918 WP_023302328.1 alpha/beta hydrolase -
CNR480_RS11455 2385309..2386250 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
CNR480_RS11460 2386295..2386732 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
CNR480_RS11465 2386729..2387589 - 861 WP_004146232.1 virulence factor BrkB family protein -
CNR480_RS11470 2387583..2388182 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14376.67 Da        Isoelectric Point: 9.5352

>T292120 WP_040182550.1 NZ_LS399318:c2383931-2383548 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLKLITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT292120 WP_004150355.1 NZ_LS399318:c2384173-2383931 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References