Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 837641..838118 Replicon chromosome
Accession NC_020566
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAI5S5_RS04030 Protein ID WP_000052076.1
Coordinates 837641..837829 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAI5S5_RS04035 Protein ID WP_001059690.1
Coordinates 837858..838118 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAI5S5_RS04000 833635..834156 + 522 WP_000824485.1 hypothetical protein -
SAI5S5_RS04005 834497..835183 + 687 WP_000141557.1 thermonuclease family protein -
SAI5S5_RS04010 835540..835740 + 201 WP_001059082.1 cold-shock protein -
SAI5S5_RS04015 836232..836450 - 219 WP_000005886.1 hypothetical protein -
SAI5S5_RS04020 836512..836796 - 285 WP_001004399.1 hypothetical protein -
SAI5S5_RS04025 836884..837453 - 570 WP_001106654.1 hypothetical protein -
SAI5S5_RS04030 837641..837829 - 189 WP_000052076.1 hypothetical protein Toxin
SAI5S5_RS04035 837858..838118 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAI5S5_RS04040 838459..838662 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAI5S5_RS04045 838659..838895 - 237 WP_000349581.1 hypothetical protein -
SAI5S5_RS04050 839120..839701 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAI5S5_RS04055 839774..840391 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SAI5S5_RS04060 840546..841040 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAI5S5_RS04065 841439..841861 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAI5S5_RS04070 842009..842725 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T29212 WP_000052076.1 NC_020566:c837829-837641 [Staphylococcus aureus subsp. aureus ST228]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T29212 NC_020566:c837829-837641 [Staphylococcus aureus subsp. aureus ST228]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT29212 WP_001059690.1 NC_020566:c838118-837858 [Staphylococcus aureus subsp. aureus ST228]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT29212 NC_020566:c838118-837858 [Staphylococcus aureus subsp. aureus ST228]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References