Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1820297..1821110 Replicon chromosome
Accession NZ_LS399318
Organism Klebsiella pneumoniae isolate CNR48

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag CNR480_RS08800 Protein ID WP_101516303.1
Coordinates 1820297..1820833 (-) Length 179 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag CNR480_RS08805 Protein ID WP_023343051.1
Coordinates 1820844..1821110 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNR480_RS08795 1819128..1820249 + 1122 WP_012737335.1 cupin domain-containing protein -
CNR480_RS08800 1820297..1820833 - 537 WP_101516303.1 GNAT family N-acetyltransferase Toxin
CNR480_RS08805 1820844..1821110 - 267 WP_023343051.1 DUF1778 domain-containing protein Antitoxin
CNR480_RS08810 1821213..1822646 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
CNR480_RS08815 1822636..1823319 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
CNR480_RS08820 1823492..1824877 + 1386 WP_040182471.1 efflux transporter outer membrane subunit -
CNR480_RS08825 1824895..1825239 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 179 a.a.        Molecular weight: 19951.87 Da        Isoelectric Point: 5.7068

>T292117 WP_101516303.1 NZ_LS399318:c1820833-1820297 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSN
LLFYPTKSIEQLFTDDES

Download         Length: 537 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT292117 WP_023343051.1 NZ_LS399318:c1821110-1820844 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References