Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2799401..2801000 Replicon chromosome
Accession NZ_LS398604
Organism Bordetella pertussis strain VS377 isolate Bordetella pertussis

Toxin (Protein)


Gene name hipA Uniprot ID Q7VVM6
Locus tag VS401_RS13630 Protein ID WP_003816876.1
Coordinates 2799401..2800741 (-) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag VS401_RS13635 Protein ID WP_019247974.1
Coordinates 2800743..2801000 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VS401_RS13610 2794627..2795448 - 822 WP_014905903.1 IclR family transcriptional regulator -
VS401_RS13615 2795863..2796941 - 1079 Protein_2635 tellurite resistance/C4-dicarboxylate transporter family protein -
VS401_RS13620 2797173..2798603 - 1431 WP_019247976.1 MFS transporter -
VS401_RS13625 2798616..2799305 + 690 WP_010931038.1 TetR/AcrR family transcriptional regulator -
VS401_RS13630 2799401..2800741 - 1341 WP_003816876.1 type II toxin-antitoxin system HipA family toxin Toxin
VS401_RS13635 2800743..2801000 - 258 WP_019247974.1 helix-turn-helix domain-containing protein Antitoxin
VS401_RS13645 2801354..2802946 - 1593 WP_010931040.1 glutamine-hydrolyzing GMP synthase -
VS401_RS13650 2803043..2804503 - 1461 WP_003812368.1 IMP dehydrogenase -
VS401_RS13655 2804726..2805337 + 612 WP_010931041.1 DUF2239 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49632.79 Da        Isoelectric Point: 7.4158

>T292113 WP_003816876.1 NZ_LS398604:c2800741-2799401 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Download         Length: 1341 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8815.04 Da        Isoelectric Point: 7.1642

>AT292113 WP_019247974.1 NZ_LS398604:c2801000-2800743 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7VVM6

Antitoxin

Source ID Structure

References