Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4763688..4764185 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag JMX41_RS23785 Protein ID WP_001173343.1
Coordinates 4763688..4763861 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag JMX41_RS23790 Protein ID WP_000398619.1
Coordinates 4763889..4764185 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS23775 4760358..4761815 + 1458 WP_000856813.1 dipeptide/tripeptide permease DtpC -
JMX41_RS23780 4762052..4763569 + 1518 WP_000003806.1 lysine--tRNA ligase -
JMX41_RS23785 4763688..4763861 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
JMX41_RS23790 4763889..4764185 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
JMX41_RS23795 4764414..4764686 - 273 WP_000405647.1 N-acetyltransferase -
JMX41_RS23800 4764698..4764928 - 231 WP_000371704.1 (4Fe-4S)-binding protein -
JMX41_RS23805 4765109..4766740 + 1632 WP_001216448.1 sensor histidine kinase -
JMX41_RS23810 4766737..4767456 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T292084 WP_001173343.1 NZ_LR898874:c4763861-4763688 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT292084 WP_000398619.1 NZ_LR898874:c4764185-4763889 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References