Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4630494..4631089 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag JMX41_RS23110 Protein ID WP_000239577.1
Coordinates 4630494..4630844 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag JMX41_RS23115 Protein ID WP_001223208.1
Coordinates 4630838..4631089 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS23090 4625943..4626965 - 1023 WP_001572298.1 ABC transporter permease -
JMX41_RS23095 4626979..4628481 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
JMX41_RS23100 4628621..4629577 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JMX41_RS23105 4629887..4630417 + 531 WP_000055070.1 inorganic diphosphatase -
JMX41_RS23110 4630494..4630844 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
JMX41_RS23115 4630838..4631089 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JMX41_RS23120 4631301..4631642 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JMX41_RS23125 4631645..4635424 - 3780 WP_001572297.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T292083 WP_000239577.1 NZ_LR898874:c4630844-4630494 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT292083 WP_001223208.1 NZ_LR898874:c4631089-4630838 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References