Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 4341756..4342306 | Replicon | chromosome |
Accession | NZ_LR898874 | ||
Organism | Escherichia coli isolate MSB1_4I-sc-2280412 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PDG4 |
Locus tag | JMX41_RS21680 | Protein ID | WP_001160966.1 |
Coordinates | 4341756..4342070 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1NMQ0 |
Locus tag | JMX41_RS21685 | Protein ID | WP_000125568.1 |
Coordinates | 4342073..4342306 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMX41_RS21655 | 4337431..4338717 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
JMX41_RS21660 | 4338717..4339706 | + | 990 | WP_000241224.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
JMX41_RS21665 | 4339703..4340524 | + | 822 | WP_001065381.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
JMX41_RS21670 | 4340527..4340904 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
JMX41_RS21675 | 4340911..4341759 | + | 849 | WP_001570924.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
JMX41_RS21680 | 4341756..4342070 | - | 315 | WP_001160966.1 | CcdB family protein | Toxin |
JMX41_RS21685 | 4342073..4342306 | - | 234 | WP_000125568.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
JMX41_RS21690 | 4342392..4342871 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
JMX41_RS21695 | 4343063..4344925 | - | 1863 | WP_000377117.1 | glutathione-regulated potassium-efflux system protein KefC | - |
JMX41_RS21700 | 4344918..4345448 | - | 531 | WP_000600725.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
JMX41_RS21705 | 4345556..4346887 | - | 1332 | WP_001183201.1 | MFS transporter | - |
JMX41_RS21710 | 4346946..4347233 | - | 288 | WP_001570923.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.72 Da Isoelectric Point: 9.0851
>T292081 WP_001160966.1 NZ_LR898874:c4342070-4341756 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G815 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829GEF2 |