292078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3946943..3947780 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name itaT Uniprot ID V0SED1
Locus tag JMX41_RS19710 Protein ID WP_000227787.1
Coordinates 3947238..3947780 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID B1LJI1
Locus tag JMX41_RS19705 Protein ID WP_001353405.1
Coordinates 3946943..3947254 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS19680 3941963..3942910 + 948 WP_001571023.1 cytochrome o ubiquinol oxidase subunit II -
JMX41_RS19685 3942932..3944923 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
JMX41_RS19690 3944913..3945527 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
JMX41_RS19695 3945527..3945856 + 330 WP_000019803.1 cytochrome o ubiquinol oxidase subunit IV -
JMX41_RS19700 3945868..3946758 + 891 WP_000971328.1 heme o synthase -
JMX41_RS19705 3946943..3947254 + 312 WP_001353405.1 DUF1778 domain-containing protein Antitoxin
JMX41_RS19710 3947238..3947780 + 543 WP_000227787.1 GNAT family N-acetyltransferase Toxin
JMX41_RS19715 3947836..3948771 - 936 WP_001571021.1 sel1 repeat family protein -
JMX41_RS19720 3949178..3950542 + 1365 WP_001000966.1 MFS transporter -
JMX41_RS19725 3950670..3951161 - 492 WP_001138904.1 nucleotide binding protein YajQ -
JMX41_RS19730 3951329..3952240 + 912 WP_001571020.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19946.24 Da        Isoelectric Point: 8.8951

>T292078 WP_000227787.1 NZ_LR898874:3947238-3947780 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHRALPIKGVYLDADPAAINFYTRLGFVQLSA
RPNVFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11370.09 Da        Isoelectric Point: 10.4825

>AT292078 WP_001353405.1 NZ_LR898874:3946943-3947254 [Escherichia coli]
MPGKTVALPDIDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GE43

Antitoxin

Source ID Structure
AlphaFold DB A0A829G7G3

References