292077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3912071..3912689 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JMX41_RS19535 Protein ID WP_001291435.1
Coordinates 3912471..3912689 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JMX41_RS19530 Protein ID WP_000344800.1
Coordinates 3912071..3912445 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS19520 3907161..3908354 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMX41_RS19525 3908377..3911526 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
JMX41_RS19530 3912071..3912445 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JMX41_RS19535 3912471..3912689 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JMX41_RS19540 3912861..3913412 + 552 WP_001571034.1 maltose O-acetyltransferase -
JMX41_RS19545 3913528..3913998 + 471 WP_000136192.1 YlaC family protein -
JMX41_RS19550 3914162..3915712 + 1551 WP_001571032.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JMX41_RS19555 3915753..3916106 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JMX41_RS19565 3916485..3916796 + 312 WP_000409911.1 MGMT family protein -
JMX41_RS19570 3916827..3917399 - 573 WP_000779836.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T292077 WP_001291435.1 NZ_LR898874:3912471-3912689 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT292077 WP_000344800.1 NZ_LR898874:3912071-3912445 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References