292069

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2659502..2660028 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMX41_RS13035 Protein ID WP_000323025.1
Coordinates 2659502..2659789 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JMX41_RS13040 Protein ID WP_000534858.1
Coordinates 2659789..2660028 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS12990 2654526..2654741 - 216 WP_000839590.1 phage lysis protein EssD -
JMX41_RS12995 2655495..2655710 - 216 WP_000066484.1 cold shock-like protein CspB -
JMX41_RS13000 2656011..2656223 + 213 WP_000087756.1 cold shock-like protein CspF -
JMX41_RS13005 2656278..2656367 + 90 WP_120795389.1 hypothetical protein -
JMX41_RS13010 2656645..2657397 - 753 WP_001571462.1 antitermination protein -
JMX41_RS13015 2657411..2658460 - 1050 WP_001265198.1 DUF968 domain-containing protein -
JMX41_RS13020 2658462..2658740 - 279 WP_032147666.1 hypothetical protein -
JMX41_RS13025 2658807..2659058 - 252 WP_000980994.1 hypothetical protein -
JMX41_RS13030 2659275..2659430 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JMX41_RS13035 2659502..2659789 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMX41_RS13040 2659789..2660028 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMX41_RS13045 2660053..2660358 + 306 WP_001326990.1 hypothetical protein -
JMX41_RS13050 2660561..2660893 + 333 WP_001301033.1 protein FlxA -
JMX41_RS13055 2661330..2662643 - 1314 WP_001571463.1 ISNCY family transposase -
JMX41_RS13060 2663412..2663698 - 287 Protein_2565 hypothetical protein -
JMX41_RS13065 2664309..2664665 - 357 WP_001310834.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2629105..2675512 46407


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T292069 WP_000323025.1 NZ_LR898874:c2659789-2659502 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT292069 WP_000534858.1 NZ_LR898874:c2660028-2659789 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References