Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2659502..2660028 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMX41_RS13035 Protein ID WP_000323025.1
Coordinates 2659502..2659789 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JMX41_RS13040 Protein ID WP_000534858.1
Coordinates 2659789..2660028 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS12990 2654526..2654741 - 216 WP_000839590.1 phage lysis protein EssD -
JMX41_RS12995 2655495..2655710 - 216 WP_000066484.1 cold shock-like protein CspB -
JMX41_RS13000 2656011..2656223 + 213 WP_000087756.1 cold shock-like protein CspF -
JMX41_RS13005 2656278..2656367 + 90 WP_120795389.1 hypothetical protein -
JMX41_RS13010 2656645..2657397 - 753 WP_001571462.1 antitermination protein -
JMX41_RS13015 2657411..2658460 - 1050 WP_001265198.1 DUF968 domain-containing protein -
JMX41_RS13020 2658462..2658740 - 279 WP_032147666.1 hypothetical protein -
JMX41_RS13025 2658807..2659058 - 252 WP_000980994.1 hypothetical protein -
JMX41_RS13030 2659275..2659430 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JMX41_RS13035 2659502..2659789 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMX41_RS13040 2659789..2660028 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMX41_RS13045 2660053..2660358 + 306 WP_001326990.1 hypothetical protein -
JMX41_RS13050 2660561..2660893 + 333 WP_001301033.1 protein FlxA -
JMX41_RS13055 2661330..2662643 - 1314 WP_001571463.1 ISNCY family transposase -
JMX41_RS13060 2663412..2663698 - 287 Protein_2565 hypothetical protein -
JMX41_RS13065 2664309..2664665 - 357 WP_001310834.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2629105..2675512 46407


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T292069 WP_000323025.1 NZ_LR898874:c2659789-2659502 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT292069 WP_000534858.1 NZ_LR898874:c2660028-2659789 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References