Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2116324..2117108 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag JMX41_RS10245 Protein ID WP_000613626.1
Coordinates 2116324..2116818 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B1LI61
Locus tag JMX41_RS10250 Protein ID WP_001110446.1
Coordinates 2116815..2117108 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS10225 2111517..2112614 + 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -
JMX41_RS10230 2112614..2113555 + 942 WP_001571250.1 flagellar assembly peptidoglycan hydrolase FlgJ -
JMX41_RS10235 2113621..2115264 + 1644 WP_000096450.1 flagellar hook-associated protein FlgK -
JMX41_RS10240 2115276..2116229 + 954 WP_001212791.1 flagellar hook-associated protein FlgL -
JMX41_RS10245 2116324..2116818 - 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
JMX41_RS10250 2116815..2117108 - 294 WP_001110446.1 DUF1778 domain-containing protein Antitoxin
JMX41_RS10255 2117242..2120427 - 3186 WP_000827392.1 ribonuclease E -
JMX41_RS10260 2121000..2121959 + 960 WP_000846343.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T292060 WP_000613626.1 NZ_LR898874:c2116818-2116324 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11079.67 Da        Isoelectric Point: 10.5423

>AT292060 WP_001110446.1 NZ_LR898874:c2117108-2116815 [Escherichia coli]
MPAANNIPARRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G775

References