Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1140788..1141371 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name mazF Uniprot ID D8A488
Locus tag JMX41_RS05620 Protein ID WP_000254734.1
Coordinates 1141036..1141371 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A376LU34
Locus tag JMX41_RS05615 Protein ID WP_001571822.1
Coordinates 1140788..1141036 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS05605 1137127..1138428 + 1302 WP_001571823.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
JMX41_RS05610 1138476..1140710 + 2235 WP_000226815.1 GTP pyrophosphokinase -
JMX41_RS05615 1140788..1141036 + 249 WP_001571822.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JMX41_RS05620 1141036..1141371 + 336 WP_000254734.1 endoribonuclease MazF Toxin
JMX41_RS05625 1141443..1142234 + 792 WP_001071655.1 nucleoside triphosphate pyrophosphohydrolase -
JMX41_RS05630 1142462..1144099 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
JMX41_RS05635 1144186..1145484 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1145610..1146938 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

Antitoxin PemI-like

(2-82)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12195.20 Da        Isoelectric Point: 8.7218

>T292059 WP_000254734.1 NZ_LR898874:1141036-1141371 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKR
IAWRARGVTKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9328.71 Da        Isoelectric Point: 4.4665

>AT292059 WP_001571822.1 NZ_LR898874:1140788-1141036 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVSDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FR63

Antitoxin

Source ID Structure
AlphaFold DB A0A376LU34

References