Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 310130..310761 Replicon chromosome
Accession NZ_LR898874
Organism Escherichia coli isolate MSB1_4I-sc-2280412

Toxin (Protein)


Gene name hicA Uniprot ID D8A4M2
Locus tag JMX41_RS01395 Protein ID WP_001259770.1
Coordinates 310130..310405 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag JMX41_RS01400 Protein ID WP_000593555.1
Coordinates 310402..310761 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX41_RS01380 305134..306201 + 1068 WP_000361497.1 HlyD family efflux transporter periplasmic adaptor subunit -
JMX41_RS01385 306198..308933 + 2736 WP_001572026.1 ribosome-associated ATPase/putative transporter RbbA -
JMX41_RS01390 308933..310057 + 1125 WP_001314210.1 ABC transporter permease -
JMX41_RS01395 310130..310405 + 276 WP_001259770.1 type II toxin-antitoxin system HicA family toxin Toxin
JMX41_RS01400 310402..310761 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMX41_RS01405 310811..311671 - 861 WP_001131792.1 class II aldolase -
JMX41_RS01410 311703..311972 - 270 WP_000949581.1 HPr family phosphocarrier protein -
JMX41_RS01415 311962..313470 - 1509 WP_001329801.1 carbohydrate kinase -
JMX41_RS01420 313463..314821 - 1359 WP_201555571.1 PTS galactitol transporter subunit IIC -
JMX41_RS01425 314895..315176 - 282 WP_000084021.1 PTS sugar transporter subunit IIB -
JMX41_RS01430 315173..315646 - 474 WP_001572025.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 290480..310761 20281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10170.90 Da        Isoelectric Point: 10.6128

>T292055 WP_001259770.1 NZ_LR898874:310130-310405 [Escherichia coli]
MRTLVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT292055 WP_000593555.1 NZ_LR898874:310402-310761 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FQ35

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References