Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3384534..3385152 Replicon chromosome
Accession NZ_LR898868
Organism Escherichia coli isolate MSB1_1D-sc-2280324

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JMX26_RS16365 Protein ID WP_001291435.1
Coordinates 3384934..3385152 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JMX26_RS16360 Protein ID WP_000344800.1
Coordinates 3384534..3384908 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX26_RS16350 3379623..3380816 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMX26_RS16355 3380839..3383988 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JMX26_RS16360 3384534..3384908 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JMX26_RS16365 3384934..3385152 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JMX26_RS16370 3385324..3385875 + 552 WP_000102564.1 maltose O-acetyltransferase -
JMX26_RS16375 3385991..3386461 + 471 WP_000136192.1 YlaC family protein -
JMX26_RS16380 3386625..3388175 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JMX26_RS16385 3388217..3388570 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JMX26_RS16395 3388949..3389260 + 312 WP_162000861.1 MGMT family protein -
JMX26_RS16400 3389291..3389863 - 573 WP_063117855.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T292044 WP_001291435.1 NZ_LR898868:3384934-3385152 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT292044 WP_000344800.1 NZ_LR898868:3384534-3384908 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References