Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2349676..2350314 Replicon chromosome
Accession NZ_LR898868
Organism Escherichia coli isolate MSB1_1D-sc-2280324

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JMX26_RS11360 Protein ID WP_000813794.1
Coordinates 2350138..2350314 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMX26_RS11355 Protein ID WP_001270286.1
Coordinates 2349676..2350092 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX26_RS11335 2344828..2345769 - 942 WP_001251313.1 ABC transporter permease -
JMX26_RS11340 2345770..2346783 - 1014 WP_113418672.1 ABC transporter ATP-binding protein -
JMX26_RS11345 2346801..2347946 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JMX26_RS11350 2348191..2349597 - 1407 WP_113418670.1 PLP-dependent aminotransferase family protein -
JMX26_RS11355 2349676..2350092 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMX26_RS11360 2350138..2350314 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMX26_RS11365 2350536..2350766 + 231 WP_000494244.1 YncJ family protein -
JMX26_RS11370 2350858..2352819 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMX26_RS11375 2352892..2353428 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
JMX26_RS11380 2353481..2354695 + 1215 WP_071597387.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2354735..2356000 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T292043 WP_000813794.1 NZ_LR898868:c2350314-2350138 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT292043 WP_001270286.1 NZ_LR898868:c2350092-2349676 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References