292030

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5319071..5319679 Replicon chromosome
Accession NZ_LR898867
Organism Pseudomonas aeruginosa isolate MINF_3A-sc-2280432

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag JMX72_RS24975 Protein ID WP_019486378.1
Coordinates 5319071..5319418 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag JMX72_RS24980 Protein ID WP_003114155.1
Coordinates 5319428..5319679 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX72_RS24955 5314097..5315128 + 1032 WP_003158906.1 AAA family ATPase -
JMX72_RS24960 5315106..5317616 + 2511 WP_003160813.1 S8 family peptidase -
JMX72_RS24965 5317715..5318020 - 306 WP_003158903.1 helix-turn-helix domain-containing protein -
JMX72_RS24970 5318142..5318783 + 642 WP_003158902.1 substrate-binding domain-containing protein -
JMX72_RS24975 5319071..5319418 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX72_RS24980 5319428..5319679 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMX72_RS24985 5319893..5320876 - 984 WP_033990852.1 tyrosine-type recombinase/integrase -
JMX72_RS24990 5320876..5322168 - 1293 WP_033990854.1 hypothetical protein -
JMX72_RS24995 5322398..5323672 - 1275 WP_033990855.1 zonular occludens toxin family protein -
JMX72_RS25000 5323676..5324032 - 357 WP_003114150.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ere(A) / floR / tet(G) / aph(6)-Id / aph(3'')-Ib / blaCARB-2 / sul1 - 5227934..5331597 103663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T292030 WP_019486378.1 NZ_LR898867:c5319418-5319071 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT292030 WP_003114155.1 NZ_LR898867:c5319679-5319428 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References