Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5102924..5104516 Replicon chromosome
Accession NZ_LR898867
Organism Pseudomonas aeruginosa isolate MINF_3A-sc-2280432

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMX72_RS23930 Protein ID WP_201720825.1
Coordinates 5103191..5104516 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID W6RJ44
Locus tag JMX72_RS23925 Protein ID WP_003459718.1
Coordinates 5102924..5103190 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX72_RS23900 5098283..5099317 - 1035 WP_010487136.1 NADP-dependent oxidoreductase -
JMX72_RS23905 5099430..5100023 - 594 WP_201720823.1 TetR/AcrR family transcriptional regulator -
JMX72_RS23910 5100414..5101034 + 621 WP_010487132.1 glutathione S-transferase -
JMX72_RS23915 5101651..5101854 + 204 Protein_4732 hypothetical protein -
JMX72_RS23920 5102072..5102875 - 804 WP_201720824.1 inositol monophosphatase -
JMX72_RS23925 5102924..5103190 - 267 WP_003459718.1 helix-turn-helix domain-containing protein Antitoxin
JMX72_RS23930 5103191..5104516 - 1326 WP_201720825.1 HipA domain-containing protein Toxin
JMX72_RS23935 5105066..5106271 + 1206 WP_201720826.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49035.64 Da        Isoelectric Point: 5.0241

>T292029 WP_201720825.1 NZ_LR898867:c5104516-5103191 [Pseudomonas aeruginosa]
MHNLTLQVYRDGQWRNAMELRFEQPEEGLEGACAYGYHQGYLVDSLESVGTRLNVAVSAAYPLGWDSWRDKKAPAFLFDI
LPSGAARRFLLKRLGGERPEGLNLDLYLLGRCTPAPIGNLRIKESVEAIAGSPVLGFTRDEVISRDSRFLEYAYEQGAAI
GGATGAGGEAPKLLLTEDRHGALHPDAVLPDADAVQHWFVKFARNKASQTDQDILRSEYCFYRAVQQLGMDTVAAEGLAL
EEGSKPSLWMHRFDREISPAGVGRTAVESMYSLCGVTEAGSYMLHTQVLGKLVALWRAVGQEQQVGDLVFEYMRRDLLNQ
ILGNSDNHGRNTAILRSEQGVRLAPIYDLAPMVMDEEGVTRTTKWPKHIELAGEVNWRAACDEVAEWIDADELFQRLQLA
AQDLLALPDLLSAQGLPDSTMSHPRIALRNLQQRMLQWGLV

Download         Length: 1326 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9933.55 Da        Isoelectric Point: 10.9502

>AT292029 WP_003459718.1 NZ_LR898867:c5103190-5102924 [Pseudomonas aeruginosa]
MDILERNRILNELQQQLASGEITIGGAVRRLRKEVTGLQQARFAQMCKLSLRALRQLELDESNPTVQTLNSVFNPFGMQV
GIVPKTPR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W6RJ44

References