Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4745708..4746966 Replicon chromosome
Accession NZ_LR898867
Organism Pseudomonas aeruginosa isolate MINF_3A-sc-2280432

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag JMX72_RS22340 Protein ID WP_003086331.1
Coordinates 4745708..4746463 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag JMX72_RS22345 Protein ID WP_003086329.1
Coordinates 4746598..4746966 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX72_RS22330 4740879..4743422 + 2544 WP_031686396.1 acyl-homoserine-lactone acylase QuiP -
JMX72_RS22335 4743577..4744938 - 1362 WP_073647918.1 DNA recombination protein RmuC -
JMX72_RS22340 4745708..4746463 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
JMX72_RS22345 4746598..4746966 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
JMX72_RS22350 4747039..4748325 - 1287 WP_031756378.1 FAD-binding oxidoreductase -
JMX72_RS22355 4748381..4749970 - 1590 WP_074241293.1 aldehyde dehydrogenase family protein -
JMX72_RS22360 4750049..4750525 + 477 WP_003086322.1 hypothetical protein -
JMX72_RS22365 4750528..4750803 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T292028 WP_003086331.1 NZ_LR898867:c4746463-4745708 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT292028 WP_003086329.1 NZ_LR898867:c4746966-4746598 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References