Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3738936..3740156 Replicon chromosome
Accession NZ_LR898867
Organism Pseudomonas aeruginosa isolate MINF_3A-sc-2280432

Toxin (Protein)


Gene name vapC Uniprot ID A0A3S3XIW1
Locus tag JMX72_RS17505 Protein ID WP_033991668.1
Coordinates 3739578..3740156 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JMX72_RS17500 Protein ID WP_003088112.1
Coordinates 3738936..3739490 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX72_RS17475 3734504..3735055 + 552 WP_003132721.1 XRE family transcriptional regulator -
JMX72_RS17480 3735052..3735450 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
JMX72_RS17485 3735463..3735786 - 324 WP_003102734.1 multidrug efflux SMR transporter -
JMX72_RS17490 3736117..3736578 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
JMX72_RS17495 3736583..3738778 + 2196 WP_003139882.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
JMX72_RS17500 3738936..3739490 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
JMX72_RS17505 3739578..3740156 + 579 WP_033991668.1 HD domain-containing protein Toxin
JMX72_RS17510 3740266..3741453 - 1188 WP_003132729.1 HlyD family efflux transporter periplasmic adaptor subunit -
JMX72_RS17515 3741443..3743614 - 2172 WP_023106617.1 type I secretion system permease/ATPase -
JMX72_RS17520 3743604..3744881 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21947.77 Da        Isoelectric Point: 5.3655

>T292027 WP_033991668.1 NZ_LR898867:3739578-3740156 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLFQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT292027 WP_003088112.1 NZ_LR898867:3738936-3739490 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3XIW1

Antitoxin

Source ID Structure

References