Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1861944..1863452 Replicon chromosome
Accession NZ_LR898867
Organism Pseudomonas aeruginosa isolate MINF_3A-sc-2280432

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JMX72_RS08650 Protein ID WP_074198311.1
Coordinates 1861944..1862531 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag JMX72_RS08655 Protein ID WP_003091607.1
Coordinates 1862598..1863452 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX72_RS08645 1858199..1861678 - 3480 WP_003091610.1 hybrid sensor histidine kinase/response regulator -
JMX72_RS08650 1861944..1862531 + 588 WP_074198311.1 GNAT family N-acetyltransferase Toxin
JMX72_RS08655 1862598..1863452 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
JMX72_RS08660 1863549..1865714 + 2166 WP_033990934.1 TonB-dependent receptor family protein -
JMX72_RS08665 1865889..1867763 + 1875 WP_003117607.1 MFS transporter -
JMX72_RS08670 1867824..1868033 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21931.26 Da        Isoelectric Point: 9.8676

>T292026 WP_074198311.1 NZ_LR898867:1861944-1862531 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKATLEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT292026 WP_003091607.1 NZ_LR898867:1862598-1863452 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References