Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 114998..115641 Replicon plasmid 2
Accession NZ_LR890752
Organism Klebsiella pneumoniae isolate KSB1_8C-sc-2280241

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JMW25_RS26215 Protein ID WP_048298725.1
Coordinates 114998..115414 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag JMW25_RS26220 Protein ID WP_001261276.1
Coordinates 115411..115641 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW25_RS26200 110488..111456 - 969 WP_201515199.1 IS5 family transposase -
JMW25_RS26205 111718..113241 - 1524 WP_117282697.1 EAL domain-containing protein -
JMW25_RS26215 114998..115414 - 417 WP_048298725.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW25_RS26220 115411..115641 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMW25_RS26225 115894..118470 - 2577 WP_053067542.1 EstP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..174054 174054


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15094.58 Da        Isoelectric Point: 8.5403

>T292024 WP_048298725.1 NZ_LR890752:c115414-114998 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT292024 WP_001261276.1 NZ_LR890752:c115641-115411 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References