Detailed information of TA system TA292021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4902847..4904528
• Replicon: chromosome
• Accession: NZ_LR890751
• Organism: Klebsiella pneumoniae isolate KSB1_8C-sc-2280241

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: JMW25_RS23825
• Protein ID: WP_004178299.1
• Coordinates: 4902847..4903764 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: JMW25_RS23830
• Protein ID: WP_004177809.1
• Coordinates: 4903770..4904528 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW25_RS23805	4898153..4899673	+	1521	WP_201566729.1	sugar ABC transporter ATP-binding protein	-
JMW25_RS23810	4899670..4900668	+	999	WP_002885172.1	ribose ABC transporter permease	-
JMW25_RS23815	4900699..4901640	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JMW25_RS23820	4901715..4902722	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
JMW25_RS23825	4902847..4903764	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMW25_RS23830	4903770..4904528	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMW25_RS23835	4904614..4905342	-	729	WP_004178298.1	response regulator transcription factor	-
JMW25_RS23840	4905615..4907762	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMW25_RS23845	4907759..4907902	-	144	WP_022631365.1	hypothetical protein	-
JMW25_RS23850	4908340..4909026	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T292021 WP_004178299.1 NZ_LR890751:c4903764-4902847 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT292021 WP_004177809.1 NZ_LR890751:c4904528-4903770 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05