Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 29610..30520 | Replicon | plasmid 3 |
| Accession | NZ_LR890737 | ||
| Organism | Klebsiella pneumoniae isolate INF323-sc-2280125 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | JMX74_RS27025 | Protein ID | WP_004026354.1 |
| Coordinates | 30050..30520 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | JMX74_RS27020 | Protein ID | WP_099745242.1 |
| Coordinates | 29610..30053 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMX74_RS26995 | 25980..26393 | + | 414 | WP_099745240.1 | NB-ARC domain protein | - |
| JMX74_RS27000 | 26456..27130 | + | 675 | Protein_39 | hypothetical protein | - |
| JMX74_RS27005 | 27130..27462 | + | 333 | Protein_40 | transposase | - |
| JMX74_RS27010 | 27816..28238 | + | 423 | WP_004197884.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| JMX74_RS27015 | 28238..29509 | + | 1272 | WP_099745241.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| JMX74_RS27020 | 29610..30053 | + | 444 | WP_099745242.1 | DUF2384 domain-containing protein | Antitoxin |
| JMX74_RS27025 | 30050..30520 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| JMX74_RS27030 | 30631..30891 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| JMX74_RS27035 | 31463..32644 | - | 1182 | WP_109037802.1 | IS481 family transposase | - |
| JMX74_RS27040 | 32716..32874 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| JMX74_RS27045 | 33253..33495 | - | 243 | WP_086528906.1 | hypothetical protein | - |
| JMX74_RS27050 | 33525..33692 | - | 168 | WP_196241044.1 | hypothetical protein | - |
| JMX74_RS27055 | 34081..35055 | + | 975 | WP_196241043.1 | Hok/Gef family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla | 1..217238 | 217238 | |
| - | inside | IScluster/Tn | - | - | 24399..32644 | 8245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T292007 WP_004026354.1 NZ_LR890737:30050-30520 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16494.83 Da Isoelectric Point: 10.2498
>AT292007 WP_099745242.1 NZ_LR890737:29610-30053 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPAELMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPAELMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|