Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4668758..4669274 Replicon chromosome
Accession NZ_LR890735
Organism Klebsiella pneumoniae isolate INF323-sc-2280125

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JMX74_RS23010 Protein ID WP_134919476.1
Coordinates 4668758..4669042 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMX74_RS23015 Protein ID WP_101972099.1
Coordinates 4669032..4669274 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX74_RS22985 4664242..4664550 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMX74_RS22990 4664635..4664808 + 174 WP_019725541.1 hypothetical protein -
JMX74_RS22995 4664811..4665554 + 744 WP_117030717.1 MurR/RpiR family transcriptional regulator -
JMX74_RS23000 4665911..4668049 + 2139 WP_032446556.1 anaerobic ribonucleoside-triphosphate reductase -
JMX74_RS23005 4668290..4668754 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX74_RS23010 4668758..4669042 - 285 WP_134919476.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX74_RS23015 4669032..4669274 - 243 WP_101972099.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX74_RS23020 4669352..4671262 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMX74_RS23025 4671285..4672439 - 1155 WP_002886900.1 lactonase family protein -
JMX74_RS23030 4672506..4673246 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11168.03 Da        Isoelectric Point: 10.3787

>T292004 WP_134919476.1 NZ_LR890735:c4669042-4668758 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9061.61 Da        Isoelectric Point: 6.3116

>AT292004 WP_101972099.1 NZ_LR890735:c4669274-4669032 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVCLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References