Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4563418..4564228 Replicon chromosome
Accession NZ_LR890735
Organism Klebsiella pneumoniae isolate INF323-sc-2280125

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag JMX74_RS22585 Protein ID WP_201720329.1
Coordinates 4563418..4563951 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag JMX74_RS22590 Protein ID WP_002887278.1
Coordinates 4563962..4564228 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX74_RS22580 4562249..4563370 + 1122 WP_201720328.1 cupin domain-containing protein -
JMX74_RS22585 4563418..4563951 - 534 WP_201720329.1 GNAT family N-acetyltransferase Toxin
JMX74_RS22590 4563962..4564228 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
JMX74_RS22595 4564331..4565764 - 1434 WP_201720330.1 Cu(+)/Ag(+) sensor histidine kinase -
JMX74_RS22600 4565754..4566437 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
JMX74_RS22605 4566609..4567994 + 1386 WP_201720331.1 efflux transporter outer membrane subunit -
JMX74_RS22610 4568012..4568356 + 345 WP_021462623.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19798.67 Da        Isoelectric Point: 5.2612

>T292003 WP_201720329.1 NZ_LR890735:c4563951-4563418 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGCIQLMDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT292003 WP_002887278.1 NZ_LR890735:c4564228-4563962 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References