Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2547817..2549405 Replicon chromosome
Accession NZ_LR890735
Organism Klebsiella pneumoniae isolate INF323-sc-2280125

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag JMX74_RS12655 Protein ID WP_023301940.1
Coordinates 2547817..2549139 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMX74_RS12660 Protein ID WP_002904790.1
Coordinates 2549139..2549405 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX74_RS12640 2542873..2545374 + 2502 WP_201720572.1 fimbrial biogenesis outer membrane usher protein -
JMX74_RS12645 2545362..2546366 + 1005 WP_032421320.1 type 1 fimbrial protein -
JMX74_RS12650 2546508..2547800 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX74_RS12655 2547817..2549139 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX74_RS12660 2549139..2549405 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX74_RS12665 2549792..2550118 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMX74_RS12670 2550115..2550615 - 501 WP_046654191.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX74_RS12675 2550593..2551972 - 1380 WP_201720573.1 purine permease -
JMX74_RS12680 2552318..2553472 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX74_RS12685 2553453..2554376 - 924 WP_201720574.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T291999 WP_023301940.1 NZ_LR890735:c2549139-2547817 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291999 WP_002904790.1 NZ_LR890735:c2549405-2549139 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References