Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 69456..70030 Replicon plasmid 4
Accession NZ_LR890729
Organism Klebsiella pneumoniae isolate INF102-sc-2279897

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JMX38_RS27355 Protein ID WP_114262465.1
Coordinates 69456..69779 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMX38_RS27360 Protein ID WP_049140176.1
Coordinates 69779..70030 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX38_RS27330 64907..66943 - 2037 WP_201553246.1 VWA domain-containing protein -
JMX38_RS27335 67028..67249 - 222 WP_049140180.1 hypothetical protein -
JMX38_RS27340 67588..67968 + 381 WP_053093557.1 hypothetical protein -
JMX38_RS27345 67958..68980 - 1023 WP_049140179.1 site-specific integrase -
JMX38_RS27350 69107..69466 - 360 WP_087804770.1 hypothetical protein -
JMX38_RS27355 69456..69779 - 324 WP_114262465.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX38_RS27360 69779..70030 - 252 WP_049140176.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMX38_RS27365 70149..70397 - 249 WP_087804766.1 glutaredoxin -
JMX38_RS27370 70632..70877 - 246 WP_095725670.1 hypothetical protein -
JMX38_RS27375 70874..71338 - 465 WP_095725734.1 DUF2829 domain-containing protein -
JMX38_RS27380 71430..72185 - 756 WP_201553248.1 phosphate starvation-inducible protein PhoH -
JMX38_RS27385 72265..73086 - 822 WP_201553250.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
JMX38_RS27390 73258..73869 - 612 WP_049140159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..103830 103830


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12467.39 Da        Isoelectric Point: 10.0743

>T291991 WP_114262465.1 NZ_LR890729:c69779-69456 [Klebsiella pneumoniae]
MSDNFTTKLTFKRLALAEWESLSTPIRDKFKKVLAKRLESLDSLTMPKNRLSLQHNCYKIKLKNDGYRLAYTVKNDESGT
VTVVVTVVAVDRRDEIYNELKKRLNDE

Download         Length: 324 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.51 Da        Isoelectric Point: 4.3696

>AT291991 WP_049140176.1 NZ_LR890729:c70030-69779 [Klebsiella pneumoniae]
MFTETVLAKRTSSISEFKKNPSAAMSESHGEPVAVLSHNKPAFYCVPPALFALMMDQIGDQLLLDKAMSRLDDDEVEVTL
DQL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References